Tenascin-C Suppresses Rho Activation

Tenascin-C Suppresses Activation-Induced T A1A2 of the Extracellular Matrix Protein The Alternatively Spliced Domain TnFnIII

Lymphocyte Proliferation and Cytokine Tenascin-C Suppresses Activation-Induced T A1A2 of the Extracellular Matrix Protein The Alternatively Spliced Domain TnFnIII

Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways.

A provisional matrix consisting of fibrin and fibronectin (FN) is deposited at sites of tissue damage and repair. This matrix serves as a scaffold for fibroblast migration into the wound where these cells deposit new matrix to replace lost or damaged tissue and eventually contract the matrix to bring the margins of the wound together. Tenascin-C is expressed transiently during wound repair in t...

Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4.

Syndecan-4 is a ubiquitously expressed heparan sulfate proteoglycan that modulates cell interactions with the extracellular matrix. It is transiently up-regulated during tissue repair by cells that mediate wound healing. Here, we report that syndecan-4 is essential for optimal fibroblast response to the three-dimensional fibrin-fibronectin provisional matrix that is deposited upon tissue injury...

Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C

PURPOSE To investigate the role of tenascin-C in epithelial-mesenchymal transition (EMT) of the lens epithelium during wound healing in mice. Tenascin-C is a component of the extracellular matrix in patients having post-operative capsular opacification. METHODS The crystalline lens was injured by needle puncture in tenascin-C null (KO, n=56) and wild-type (WT, n=56) mice in a C57BL/6 backgrou...